A Critical Review on Insulin Like Growth Factor-1―A Skeletal Maturity Indicator

The evaluation of growth status plays a critical role in orthodontic care preparation decisions and the adolescent growth spurt is considered an optimal time to undergo growth adjustment therapy. Different radiological and non-radiological skeletal maturity indicators with their related advantages and drawbacks have been used. One such non-radiological biomarker is insulin like Growth Factor-1 (IGF-1) that could be used to estimate the amount of available growth present to help treat jaw differences in the circumpubertal growth period as the mean levels of it have been reported to be high during this period. IGF-1 and its predictive utility in estimating the peak pubertal growth spurt used alone or in conjunction with other radiological skeletal maturity measures is globally peer-reviewed and relevant indexed reference papers separated and diligently examined. Information gleaned from the analysis of the literature showed that IGF-1 wasEfficient in the measurement of the circumpubertal growth spurt. As seen on lateral cephalograms, it had a high correlation with the cervical stages C3 and C4 as well as with the stages relating to peak pubertal growth as seen on handwrist radiographs and middle phalanx 3 (MP3) on periapical x-rays. IGF-1 has been an efficient and alternative biomarker used alone or in conjunction with other radiological biomarkers to predict the peak pubertal growth spurt. Without the danger of additional radiographic radiation, IGF-1 may be used as a possible skeletal maturity measure. Late pubertal phases show higher mean levels of IGF-1 blood spot relative to prepubertal, early pubertal, and postpubertal phases. The mandibular condyle is IGF-1 sensitive and more reactive.

Author (s) Details

Dr. A. Arif Yezdani,
Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Prof. Dr. S. Kishore Kumar
Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Dr. Kesavaram Padmavathy
Department of Microbiology, Research Laboratory for Oral-Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

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