A Brief study about Alzheimer’s Disease and Stem Cell
Alzheimer’s disease (AD) is the most prevalent kind of dementia, characterised by a rapid deterioration in one’s ability to retain memories, think coherently, and eventually function independently.
The processes responsible for maintaining normal protein composition begin to deteriorate with age, causing several alterations in the human body. The Alzheimer’s Society promotes the advancement of stem cell research in order to better understand dementia’s causes and identify novel treatments. Recent study has shown that stem cells can increase synaptic strength, microglial activity, angiogenesis, mitochondrial function, autophagy, and apoptosis in animal models of Alzheimer’s disease.
Based on recent observations showing neurogenesis decreases drastically in Alzheimer’s disease patients compared to healthy individuals, neural stem cells (NSC) are forming a new element of disease manifestation. Furthermore, the finding of exosomes produced from mesenchymal stem cells is regarded as a novel way to intercellular communication that has provided new insight on the development of disease-modifying therapeutics for Alzheimer’s disease.
Currently, the use of induced pluripotent stem cells (iPSCs) technology appears to be a potential method for developing trustworthy models, gaining a better understanding of the genesis of the pathological process of Alzheimer’s disease, and screening effective anti-AD medications.
Human pluripotent stem cells (hPSCs)-derived three-dimensional (3D) brain organoid systems have shown great promise in recreating key characteristics of AD pathogenesis, such as amyloid plaque and neurofibrillary tangle-like formations.
A. El Shawarby
Department of Histology and Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
S. M. M. Omar
Department of Histology and Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt and Histology Department, Armed Forces College of Medicine, Egypt.
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