A Biomimetic Approach towards Chemoselective Reduction of Chalcones

Chemists are now under pressure for a few days to establish eco-friendly ways for the key steps in organic synthesis due to strong environmental constraints. Chemists highly appreciate the biomimetic approach in the field of organic synthesis not only because it is close to the natural way of synthesis, but also offers an alternative to repetitive and risky multistep chemistry. By producing a high selectivity class, the use of organocatalyst in organic synthesis decorates the synthetic process. For synthetic chemists, its use in organic synthesis remains an appealing option. A biomimetic approach to chemoselective reduction of C=C double bonds in chalcones under metal and acid-free conditions, which relies on the activation of olefin by the formation of hydrogen bonds, is stated in the present chapter. The process requires only catalytic amount of ephedrine as hydrogen bond donor and utilises Hantzsch esters for transfer hydrogenation.

Author(s) Details

Dr. Vishwa Deepak Tripathi
M.K. College Laheriasarai (A Constituent Unit of Lalit Narayan Mithila University, Darbhanga, Bihar), India.

Dr. Anand Mohan Jha
M. L. T. College, Saharsa, (A Constituent Unit of B. N. Mandal University, Madhepura, Bihar), India.

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