This chapter looks into the vital and minute components of Woodfordia fruticosa’s leaves and stem barks. When it comes to treating and preventing illnesses, nutritional and catalytic abnormalities, the phytoconstituents of herbal medicinal plants and the quantity of trace elements have a significant impact on the body. The poisonous effects of metals harm both the […]

In the medical field, antibiotics are frequently used to treat a variety of infectious disorders. High death rates, rising healthcare costs, and decreasing productivity have all been linked to antimicrobial resistance. The chapter sought to highlight the most recent mechanisms and causes of antibiotic resistance in soronavirus-2, which causes severe acute respiratory syndrome (SARS-CoV-2). The […]

Background: Primary malignant brain tumours are the third leading cause of cancer-related death and morbidity globally. IDH1 mutation has also been shown to be a predictive factor in more recent WHO classifications of CNS tumours. In gliomas, the presence of an IDH1 change increases progression-free survival. Similar to this, improved outcomes in astrocytic malignancies are […]

As a psychotic illness, schizophrenia is treated with a variety of antipsychotic drugs. The Alzheimer’s drug donepezil, which improves cognition, has just received approval. Therefore, we made an effort to assess its importance for the mice models of methylphenidate-induced psychosis. Swiss albino mice (n=6) were given 5 mg/kg of methylphenidate intraperitoneally to cause psychosis (i.p). […]

The study assessed how MLIF affected human CD4+ T cells’ intrinsic and extrinsic apoptotic pathways. For 24 hours, cells were either cultured in RPMI-1640 media alone (control), or in RPMI medium with actinomycin D, MLIF, PMA, or any combination of the four. According to annexin V/propidium iodide-stained cells, cells treated with MLIF or PMA + […]

One of the widely employed rational drug design techniques to create new ligands is molecular hybridization. The molecular hybridization technique increases the biological activity of the newly synthesised pharmacophores while attenuating the detrimental effects brought on by the individual components. Thirty different forms of N-1 substituted indolyl chalcone of N-1 substituted 2-Acetyl Benzimidazole were provisionally […]

With the aid of our computer modelling techniques, the study seeks to alter the prescription drugs now used to treat Alzheimer’s disease (AD). The half maximum inhibitory concentration (IC50) value is a measurement used to determine the binding affinity of newly developed medicines to protein molecules associated with Alzheimer’s. This number represents the dosage at […]

There are several potential uses for Solid Lipid Nanoparticles (SLN) in the quickly growing field of nanotechnology, including drug delivery, research and clinical medicine, as well as other other science and technological fields. It’s common for active pharmacological compounds still in development to have poor water solubility and bioavailability. The distinct size-dependent properties of SLN […]

Diabetes Mellitus affects a lot of people worldwide. It is a metabolic condition that causes high blood glucose levels and is characterised by hyperglycemia as a result of either increased Insulin resistance or decreased Insulin production. Numerous studies have looked at the healing power of silver and zinc oxide nanoparticles on streptozotocin-induced diabetic animals. The […]

Bosentan Hydrochloride (BOS) has a large molecular weight, only a little water solubility, and eleven hydrogen bond acceptors. It has a low bioavailability as a result. BOS has recently undergone successful development of a new Solid-Self Emulsifying Drug Delivery System (S-SMEDDS) to increase its oral bioavailability by enhancing its solubility and permitting high molecular weight […]