Scientists shed new light on hepatitis B virus origins

Researchers have provided new insight on the geographical origins and world unfolds of 2 categories of the viral hepatitis virus (HBV), in step with a study in eLife.

The findings establish the HBV genotypes D and A (HBV-D and HBV-A) as having originated within the Middle East and North Africa. They conjointly reveal significant variations within the world dissemination patterns of those genotypes, adding to our understanding of each the historic and prehistoric unfold of 1 of the world’s largest microorganism pandemics. [1]

Impact of dose and duration of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B

Background: general sex hormone is employed for various medical conditions and will cause the hepatitis B virus (HBV) reactivation.

Aims: to check the impact of length and peak dose of sex hormone on the chance of infectious disease flare in patients with chronic hepatitis B (CHB). [2]

Uptake and safety of Hepatitis B vaccination during pregnancy: A Vaccine Safety Datalink study

Introduction: viral hepatitis virus (HBV) infection noninheritable throughout gestation will cause a risk to the babe at birth which will result in vital and womb-to-tomb morbidity. viral hepatitis immunizing agent (HepB) is usually recommended for anyone at enhanced risk for catching HBV infection, together with pregnant girls. restricted knowledge square measure on the market on the security of HepB administration throughout gestation.

Objectives: To assess the frequency of maternal HepB receipt among pregnant girls and judge the potential association between maternal vaccination and pre-specified maternal and babe safety outcomes. [3]

GC-MS-based metabolomics approach to diagnose depression in hepatitis B virus-infected patients with middle or old age.

Depression is concomitantly given in hepatitis B virus (HBV)-infected patients (HB). However, there’s still no objective methodology to diagnose HBV-infected patients with depression (dHB). Therefore, during this study, a gas chromatography-mass spectrographic analysis (GC-MS)-based metabolomic approach was used to profile excrement samples from fifty-nine dHB and fifty-two Hb (the coaching set) so as to spot urinary substance biomarkers for dHB. Then, forty-one dHB and thirty-five Hb (the testing set) were wont to severally validate the diagnostic generalizability of those biomarkers. In total, thirteen differential metabolites chargeable for the discrimination between dHB and Hb were known. These differential urinary metabolites belonged in the main to lipid metabolism and organic compound metabolism. [4]

Hepatitis B Vaccination Coverage and Knowledge among Healthcare Workers at a Tertiary Hospital in Jeddah, Saudi Arabia

Background: care employees in tertiary hospital area unit at the danger of exposure and attainable transmission of serum hepatitis virus (HBV) infection. This infection may be a major and necessary hazard among healthcare employees (HCWs), it’s could also be 2–10 times above within the general population.

Objectives: To discover the serum hepatitis vaccination coverage and also the level of information among HCWs.

Methods: A cross-sectional study was performed on a proportional sample of healthcare employees at random designated from a tertiary hospital, Jeddah, Saudi Arabia through stratified sampling.

Results: vaccination coverage among study cluster was sixty-three .3%. Complete HBV vaccination was considerably related to age, length of labor and profession (p=0.002, 0.038 and 0.049, respectively). [5]

Reference

[1] Scientists shed new light on hepatitis B virus origins

Date: August 7, 2018, Source: eLife (web link)

[2] Impact of dose and duration of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B

Wong GL, Yuen BW, Chan HL, Tse YK, Yip TC, Lam KL, Lui GC, Wong VW. Impact of dose and duration of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B. Liver International. (web link)

[3] Uptake and safety of Hepatitis B vaccination during pregnancy: A Vaccine Safety Datalink study

Groom HC, Irving SA, Koppolu P, Smith N, Vazquez-Benitez G, Kharbanda EO, Daley MF, Donahue JG, Getahun D, Jackson LA, Kawai AT. Uptake and safety of Hepatitis B vaccination during pregnancy: A Vaccine Safety Datalink study. Vaccine. 2018 Sep 5. (web link)

[4] GC-MS-based metabolomics approach to diagnosing depression in hepatitis B virus-infected patients with middle or old age.

Hou L, Wei X, Zhuo Y, Qin L, Yang F, Zhang L, Song X. GC-MS-based metabolomics approach to diagnose depression in hepatitis B virus-infected patients with middle or old age. Aging. 2018 Sep. (web link)

[5] Hepatitis B Vaccination Coverage and Knowledge among Healthcare Workers at a Tertiary Hospital in Jeddah, Saudi Arabia

Amal A. Hegazy1,2*, Hussain Mohammed Albar1, and Nusaybah Hussain Albar1

1Department of Family and Community Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

2Department of Community and Occupational Medicine, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt. (web link)

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