Pathogenesis of Helicobacter pylori Infection

Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world’s population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay between the host and the bacterium. [1]

Long-term sequelae of Helicobacter pylori gastritis

Chronic Helicobacter pylori gastritis has been put forward as a risk factor for development of gastric mucosal atrophy and gastric cancer. The purpose of our study was to investigate the long-term effects of H pylori gastritis on the gastric mucosa. We prospectively studied 49 subjects negative for H pylori and 58 positive subjects for a mean follow-up of 11·5 years (range 10-13 years). Serum samples were obtained at the initial and follow-up visits for determination of H pylori IgG antibodies. [2]

A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE study

Background & Aims: Direct comparisons of bismuth and proton pump inhibitor (PPI)-based triple and quadruple therapies for Helicobacter pylori eradication are lacking. [3]

Prevalence of Helicobacter pylori Infection in Patients with Dyspeptic Symptoms in Damaturu Metropolitan

Aim: To study the prevalence of Helicobacter pylori (H. pylori) contamination among dyspeptic patients in Damaturu and report on the relationship between H. pylori predominance and different age groups in the population under study. [4]

Seroprevalence of Helicobacter pylori in Adult Patients with Gastric Symptoms Attending Public Health and Diagnostic Institute, Northwest University Kano, Nigeria

Infection with Helicobacter pylori has been recognized as global problem due to its high prevalence across the world, predominantly in developing countries. [5]

Reference

[1] Kusters, J.G., van Vliet, A.H. and Kuipers, E.J., 2006. Pathogenesis of Helicobacter pylori infection. Clinical microbiology reviews19(3), pp.449-490.

[2]Kuipers, E.J., Peña, A.S., Festen, H.P.M., Meuwissen, S.G.M., Uyterlinde, A.M., Roosendaal, R., Pals, G. and Nelis, G.F., 1995. Long-term sequelae of Helicobacter pylori gastritis. The Lancet345(8964), pp.1525-1528.

[3] Katelaris, P.H., Forbes, G.M., Talley, N.J., Crotty, B., Pylori, F.T.A.P.H. and Group, S., 2002. A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE Study. Gastroenterology123(6), pp.1763-1769.

[4] Gide, S., Ibrahim, Y., Anas, G. and Alegbe, S. D. (2019) “Prevalence of Helicobacter pylori Infection in Patients with Dyspeptic Symptoms in Damaturu Metropolitan”, Journal of Advances in Microbiology, 18(2), pp. 1-8. doi: 10.9734/jamb/2019/v18i230159.

[5] A. Umar, F., A. Abdullahi, S., Muhammad, Y., Bashiru, I. and F. Sonyo, B. (2018) “Seroprevalence of Helicobacter pylori in Adult Patients with Gastric Symptoms Attending Public Health and Diagnostic Institute, Northwest University Kano, Nigeria”, Journal of Advances in Microbiology, 7(3), pp. 1-6. doi: 10.9734/JAMB/2017/38542.

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