Quality of gastric ulcer healing: a new, emerging concept

Assessment of peptic ulceration healing is typically supported a visible examination (by scrutiny in patients, or the analysis of lesion size in experimental studies), and not on histological and ultrastructural assessment of subepithelial membrane healing. This approach has light-emitting diode to the idea that the tissue layer of grossly “healed” stomachal and/or small intestine ulcers returns to traditional, either ad lib or following treatment. However, the re-epithelialized tissue layer of grossly “healed” experimental peptic ulceration has recently been found to own outstanding histological and ultrastructural abnormalities, together with reduced height, marked dilation of stomachal glands, poor differentiation and/or chronic changes in organ cells, augmented animal tissue, and disorganised microvascular network. it’s been postulated that these residual abnormalities would possibly interfere with membrane defense and will be the premise of lesion return. within the gift article, the lesion healing method and therefore the role of sodium thiopental factors, shift zone at the lesion margin, and granulation square measure mentioned. [1]

Age at Establishment of Helicobacter pylori Infection and Gastric Carcinoma, Gastric Ulcer, and Duodenal Ulcer Risk

Helicobacter pylori is a vital risk issue for internal organ cancer, peptic ulceration, and peptic ulceration, nevertheless most infected persons don’t develop sickness. we have a tendency to examined 2 correlates of acquisition age, sibship size and birth order, to judge the hypothesis that youth acquisition of H. pylori may be a risk issue for the event of those sicknesses. In earlier nested case-control studies of a cohort of Japanese yank men in Hawaii, proof of H. pylori infection was related to the event of internal organ cancer or gastric or small intestine ulceration throughout the following amount, 1968–1989. this analysis enclosed 102, 147, and sixty four men United Nations agency developed glandular cancer of the distal abdomen, peptic ulceration, and peptic ulceration, severally, and a matched management for every. Sibship size and birth order information were analyzed as risk factors for development of those diseases. H. pylori-infected however not H. pylori-uninfected men from larger sibships (odds magnitude relation, 2.06) and of upper birth order (odds magnitude relation, 1.67) were at enlarged risk for developing internal organ cancer. H. [2]


A double-blind, placebo-controlled study was disbursed to ascertain whether or not the artificial E autacoid, misoprostol, would forestall peptic ulcer elicited by non-steroidal anti-inflammatory drug medication (NSAIDs). 420 patients with degenerative joint disease and NSAID-associated abdominal pain were studied; they were receiving nonsteroidal anti-inflammatory, piroxicam, or nonsteroidal anti-inflammatory. scrutiny was done at entry and once one, 2, and three months of continuous treatment with a hundred μg or two hundred μg misoprostol or placebo, given fourfold daily with meals and at hour, at the same time with the anti-inflammatory drug. Abdominal pain was rated severally by patients and physicians. A treatment failure was outlined as development of a peptic ulcer. stomachic ulcers (0•3 cm in diameter or greater) occurred less ofttimes.  [3]

Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue

Recently, 3 totally different autacoid E2 synthases are identified: granule prostaglandin E synthase (mPGES)-1, cytosolic PGES (cPGES), and mPGES-2; but, their role and affiliation to enzyme (COX)-2 within the peptic ulcer repair method stay unknown. Therefore, we tend to examined mPGES-1, cPGES, and mPGES-2 expression and localization within the abdomen in vitro and in vivo. Tissues were obtained from Helicobacter pylori (H. pylori)-infected patients and consisted of surgical resections of stomachic ulcers, or biopsies of stomachic ulcers or inflammation. mPGES-1 ribonucleic acid and macromolecule expression levels were examined by period of time enzyme chain reaction (PCR) and Western blot analysis, severally. mPGES-1, cPGES, and mPGES-2 localization were analyzed immunohistochemically. Induction of PGES expression in response to lymphokine (IL)-1β was examined in vitro within the polite human stomachic embryonic cell line Hs262.St. [4]

Amilioretive Effect of Aqueous Leaves Extract of Ziziphus mucronata in Ethanol Induced Gastric Ulcer Model Rats

Background: peptic ulceration may be a major problem poignant 100% of the world population. genus Ziziphus mucronata may be a plant with several reported  health promoting effects. the current study was designed to research the therapeutic impact of binary compound leaves extract on ethyl alcohol elicited peptic ulceration model in rats.

Materials and Methods: The rats weighed one hundred seventy – two hundred g were divided into four groups: Negative management, Positive management, Extract treated (250 mg/Kg), gastric antacid treated (20 mg/Kg). customary strategies were adopted within the analysis of all parameters. [5]


[1] Tarnawski, A., Stachura, J., Krause, W.J., Douglass, T.G. and Gergely, H., 1991. Quality of gastric ulcer healing: a new, emerging concept. Journal of clinical gastroenterology, 13, (Web Link)

[2] Blaser, M.J., Chyou, P.H. and Nomura, A., 1995. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer research, 55(3), (Web Link)

[3] Graham, D., Agrawal, N. and Roth, S., 1988. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. The Lancet, 332(8623), (Web Link)

[4] Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue
Katya Gudis, Atsushi Tatsuguchi, Ken Wada, Seiji Futagami, Kazuhiro Nagata, Tetsuro Hiratsuka, Yoko Shinji, Kazumasa Miyake, Taku Tsukui, Yuh Fukuda & Choitsu Sakamoto
Laboratory Investigation volume 85, (Web Link)

[5] Dandare, A., A. Zarewa, S., Abdullahi, K., Rabiu, S. and A. Onwughara, C. (2017) “Amilioretive Effect of Aqueous Leaves Extract of Ziziphus mucronata in Ethanol Induced Gastric Ulcer Model Rats”, Journal of Applied Life Sciences International, 15(2), (Web Link)

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