Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)

Preliminary studies with Combretum erythrophyllum showed antimicrobial activity against Gram-positive and Gram-negative bacteria. Seven antibacterial flavonoids were subsequently isolated by bioassay-guided fractionation, i.e. apigenin; genkwanin; 5-hydroxy-7,4′-dimethoxyflavone, rhamnocitrin; kaempferol; quercetin-5,3′-dimethylether; rhamnazin. All compounds had good activity against Vibrio cholerae and Enterococcus faecalis, with MIC values in the range of 25–50 μg/ml. Rhamnocitrin and quercetin-5,3′-dimethylether also inhibited Micrococcus luteus and Shigella sonei at 25 μg/ml. [1]

Antifungal activities of six South African Terminalia species (Combretaceae)

A serial microplate dilution method developed for bacteria was modified slightly and gave good results with several fungi. The antifungal activity of acetone, hexane, dichloromethane and methanol leaf extracts of six Terminalia species (Terminalia prunioidesTerminalia brachystemmaTerminalia sericeaTerminalia gazensisTerminalia mollis and Terminalia sambesiaca) were tested against five fungal animal pathogens (Candida albicansCryptococcus neoformansAspergillus fumigatusMicrosporum canis and Sporothrix schenkii).  [2]

The biological activity and chemistry of the southern African Combretaceae

Aim of the study

Members of the Combretaceae family are widely traded in the traditional medicine market in southern Africa. The family is also used for medicinal purposes in the rest of Africa and Asia for close to 90 medicinal indications. [3]

Antioxidants Contents of Terminalia catappa (Combretaceae) Almonds Grown in Côte d’Ivoire

Aims: To determine the antioxidants contents of almonds from fruits of Terminalia catappa L. (Combretaceae) grown in Côte d’Ivoire.

Study Design: The almonds of T. catappa were removed from the dried mature fruits harvested in different regions of Côte d’Ivoire. A pool of almonds was drawn at Laboratory and the antioxidants components were determined. [4]

Anti Diabetic activity of Terminalia superba (Combretaceae) Stem Bark Extract in Streptozotocin Induced Diabetic Rats

Aims: The present study was designed to evaluate the antidiabetic activity of the methanol stem bark extract of Terminalia superb (T. superba), a traditionally used medicinal plant in Cameroon. Place and Duration of Study: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon and Laboratoire de Pharmacologie et Physiopathologie Expérimentales, Université Montpellier I, France. Between Ferbruary 2011 and September 2011. Methodology: In one set of experiments, repeated doses of T. superba extract (37.5– 300mg/kg, p.o.) were administrated once daily for 21 days to groups of diabetic rats. In another set of experiments, acute effect of the plant extract (37.5–300mg/kg) in diabetic rats was evaluated. [5]


[1] Martini, N.D., Katerere, D.R.P. and Eloff, J.N., 2004. Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae). Journal of ethnopharmacology93(2-3), pp.207-212.

[2] Masoko, P., Picard, J. and Eloff, J.N., 2005. Antifungal activities of six south African Terminalia species (Combretaceae). Journal of Ethnopharmacology99(2), pp.301-308.

[3] Eloff, J.N., Katerere, D.R. and McGaw, L.J., 2008. The biological activity and chemistry of the southern African Combretaceae. Journal of Ethnopharmacology119(3), pp.686-699.

[4] Etienne, D.T., Christelle, K.K.A., Yves, N., Constant, K., Adama, C., Daouda, S., Ysidor, K.N.G. and Marius, B.G.H., 2017. Antioxidants Contents of Terminalia catappa (Combretaceae) Almonds Grown in Côte d’Ivoire. Archives of Current Research International, pp.1-12.

[5] Désiré, D.D.P., Benoît, N.T., Jacqueline, A., Gérard, C., Pierre, K. and Théophile, D., 2014. Anti Diabetic activity of Terminalia superba (Combretaceae) Stem Bark Extract in Streptozotocin Induced Diabetic Rats. Journal of Pharmaceutical Research International, pp.1300-1310.

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