The neonatal blood count in health and disease.I. Reference values for neutrophilic cells

Reference ranges for absolute total neutrophils/mm3, absolute immature neutrophils/mm3, and thefraction of immature to total neutrophils (I:T proportion) during the primary 28 days of life are developed from 585 peripheral blood counts obtained from 304 normal neonates and 320 counts obtained from 130 neonates with perinatal complications demonstrated to possess no statistically significant effect on neutrophil dynamics. Perinatal factors aside from bacterial disease which significantly alter neutrophil dynamics include maternal hypertension, maternal fever before delivery, hemolytic disease, and periventricular hemorrhage. The predictive value of those reference ranges in identifying bacterial disease within the first week aged varies with the neutrophil factor evaluated and therefore the clinical setting. [1]

Automation of differential blood count

A technique for automating the differential count of blood is presented. The proposed system takes, as input, color images of stained peripheral blood smears and identifies the category of every of the white blood cells (WBC), so as to work out the count of cells in each class. the method involves segmentation, feature extraction and classification. WBC segmentation may be a two-step process administered on the HSV-equivalent of the image, using k-means clustering followed by the EM-algorithm. Features extracted from the segmented cytoplasm and nucleus, are motivated by the visual cues of shape, color and texture. Various classifiers are explored on different combinations of feature sets. The results presented are supported trials conducted with normal cells. For training the classifiers, a library set of fifty patterns, with about 10 samples from each class, is used. The test data, disjoint from the training set, consists of 34 patterns, fairly represented by every class. the simplest classification accuracy of 97% is obtained using neural networks, followed by 94% using SVM. [2]

Diagnostic Decision: The Complete Blood Count and Leukocyte Differential Count: An Approach to Their Rational Application

The complete blood count and leukocyte differential count haven’t any value in screening asymptomatic members of the overall population. the entire blood count could also be useful for screening infants within the first year of life, institutionalized elderly persons, pregnant women, and up to date immigrants from Third World countries, if poor nutrition or inadequate iron intake is suspected. These tests aren’t useful for hospitalized patients, unless an abnormality is suspected or surgery with major blood loss is anticipated. it’s appropriate to get the tests when a hematologic or infectious disorder is suspected, but they’ll not affect deciding if the diagnosis is clinically evident. The leukocyte differential count makes no sense to verify an infection in most cases during which leukocytosis is present. [3]

A cartridge based Point-of-Care device for complete blood count

We demonstrate a proprietary lab-on-chip/μ TAS technology platform for a regulatory grade portable instrument for complete blood count (CBC) hematology tests including 3 part differential WBCs, RBCs, platelet and hemoglobin for rapid diagnostics at the purpose of care in resource-poor settings. Presently, diagnostics supported blood tests are confined to centralized laboratory settings, hooked in to large footprint and expensive cytometers or on a microscope, requiring trained laboratory technicians. Consequently, such facilities aren’t present in rural and semi-urban settings, where there are opportunities and challenges in delivering efficient healthcare infrastructure at a reasonable cost in resource-challenged environments. [4]

Effect of Zinc Supplementation on Blood Pressure and Complete Blood Count in Hemodialysis Patients

Objectives: Zinc is a crucial chemical element in human nutrition and its deficiency may be a worldwide problem. deficiency disease incidence is predominantly high in many diseases like ESRD (End Stage Renal Disease) patients undertaking hemodialysis (HD). Beside, hypertension and flow , may be a predictor of cardiovascular mortality in HD patients. This study investigated the consequences of zinc supplementation on vital sign (BP) and complete blood count (CBC) in HD patients.

Materials and Methods: during a randomized, double-blind, and placebo-controlled trial, Sixty-five HD patients were randomly divided into two groups. Patients in group I and group II received placebo and Zn supplementation (100 mg/day) respectively for 2 months. After withdrawing for the duration of subsequent two months, the study was continued as a crossover design for an additional two months (group I and II received zinc supplementation and placebo, respectively). Systolic and diastolic BP, cardiac ejection fraction (EF), and CBC were measured at the 0th, 60th, 120th, and 180th days. Statistical analyses were performed using SPSS software. [5]


[1] Manroe, B.L., Weinberg, A.G., Rosenfeld, C.R. and Browne, R., 1979. The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. The Journal of pediatrics, 95(1), (Web Link)

[2] Sinha, N. and Ramakrishnan, A.G., 2003, October. Automation of differential blood count. In TENCON 2003. Conference on Convergent Technologies for Asia-Pacific Region (Vol. 2, pp. 547-551). IEEE. (Web Link)

[3] Shapiro, M.F. and Greenfield, S., 1987. Diagnostic Decision: The Complete Blood Count and Leukocyte Differential Count: An Approach to Their Rational Application. Annals of internal medicine, 106(1), (Web Link)

[4] A cartridge based Point-of-Care device for complete blood count
Usama Abbasi, Prasanta Chowdhury, Sasikala Subramaniam, Prakhar Jain, Nitin Muthe, Faisal Sheikh, Subham Banerjee & V. Kumaran
Scientific Reports volume 9, (Web Link)

[5] Mazani, M., Argani, H., Rashtchizadeh, N., Banaei, S., Kazemi Arbat, B. and Rezagholizadeh, L. (2017) “Effect of Zinc Supplementation on Blood Pressure and Complete Blood Count in Hemodialysis Patients”, Asian Journal of Medicine and Health, 7(3), (Web Link)

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