Trends in Evolution of Anthelminthic Chemical Agents: Ecological, Physiological and Biochemical Adaptation in Helminth

In this study, the key anthelminthic compounds are discussed, including alternative medicine components, different types of pluripotent manufactured and naturally occurring compounds. The sections devoted to recent discoveries (Emodepside, Monepantel, Derquantel, Tribendimidine) and certain promising efforts receive a lot of attention. The overview also covers molecular mechanisms of action of anthelminthic substances, helminth adaptation to […]

Development and Validation of UV-Spectrophotometric Method for the Determination of Lornoxicam in Microsponges

Objective: To develop and verify a new UV-spectrophotometric method for estimating the amount of lornoxicam in microsponges that is specific, precise, and simple. Lornoxicam is an oxicam-class non-steroidal anti-inflammatory medication (NSAID) with analgesic, anti-inflammatory, and antipyretic (fever-reducing) effects. Thermo Scientific Evolution 201 UV-Vis spectrophotometer was used to make UV-spectrophotometric measurements with methanol as the medium. […]

Antiseptic Use in Wounds of the Lower Limb

The goal of this study is to go over all of the available research on antiseptic safety and efficacy in surgical wounds. Different antiseptic solutions, irrigation amounts, time scales, and delivery systems have been examined in order to develop evidence-based antiseptic recommendations for plastic, orthopaedic, and foot and ankle surgical operations. Methods: To find in-vitro […]

Experimental Evaluation of the Effect of Chloroform Inhalation as a Method of Euthanasia on the Cerebellum and Hippocampus of Adult Wistar Rats

In Nigeria, chloroform inhalation is a frequent method of rodent killing for study. The purpose of this study is to see how this form of sacrifice affects the cerebellum and hippocampus of Wistar rats. Twenty male Wistar rats, weighing 160 to 180 grammes, were separated into four groups, each with five rats. The control group, […]

Polycystic Ovarian Syndrome: Insights into the Recent Trends

PCOS (polycystic ovarian syndrome) is a hormonal disorder that affects millions of women around the world. Obesity, hyperandrogenism, and insulin resistance have all been identified as key triggering factors for PCOS, despite the fact that the exact cause is unknown. PCOS symptoms include menstrual irregularities, acne, hirsutism, a predisposition to central obesity, and insulin resistance […]

Phytotherapeutic Activities of Six Plant Infusions: Chemical Constituents and Antioxidant Activity

Traditional medicine is used for a variety of reasons, including cultural and economic factors as well as the ineffectiveness of many contemporary treatments. The absence of effective pharmaceutical formulations, as well as current antibiotic pathogen resistance and oxidative stress, have led to the development of new therapeutic compounds derived from plants. Several investigations have revealed […]

Potential of Saliva-Based Diagnostics to Decrease Hazardous Waste Generation

Green laboratories, which reduce environmental impact by promoting sustainable best practises such as waste minimization, have been increasingly popular in recent years. Researchers have created new technologies and verified a wide number of salivary indicators, paving the way for saliva to become a clinical reality in the near future. Saliva, like blood, includes a large […]

Poisoning; A Grave Public Health Concern

Over half a million people die each year as a result of intentional and unintentional poisoning, with low- and middle-income countries (LMIC) accounting for 84 percent of such fatalities. The clinical appearance of such instances differs depending on the age group, the cause of poisoning, the geographic region, the drugs involved, and the country’s economic […]

Cross-linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines: An Advanced Study

Mast cells are immune-regulatory cells that play a role in the inflammatory response. Mast cells are partially activated without the release of preformed mediators when GD1b generated gangliosides are cross-linked by mAbAA4. Following ganglioside cross-linking, the release of newly formed and newly synthesised mediators is investigated. The newly synthesised lipid mediators, prostaglandins D2 and E2, […]

Recent Development and Validation of a Dissolution Method for Lamotrigine Tablets by UPLC

The goal of this study was to design and validate a UPLC dissolve method for lamotrigine tablets that was accurate, precise, repeatable, and cost-effective. The UPLC technique was carried out with a 75:25 percent v/v mixture of buffer and acetonitrile. The flow rate was 0.3 ml/min, and the UV detection wavelength was 310 nm. Acquity […]