Metosartan induces so many deleterious effects in male Wistar rats treated with drug and RNase. It
causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm
count. It induces the x-chromosome desynapsis leading to testicular carcinoma. The effects are so
profound in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis in
testicular tissue mainly through intrinsic pathway which is mainly due to genotoxic agents. The drug
mainly inhibits RNase A in rat testes and has positive effect on Mitosis. Metosartan mainly effects
chromatin compaction thus increasing access to nucleases which should be confirmed in invivo.
RNase A effects the assembly of nuclear pore complex after mitosis but it does not inhibit the
synthesis of NPC.

Author (s) Details

Eswari Beeram
Department of Chemical Sciences, Sree Vidyanikethan Degree College, Andhra Pradesh, India and Department of Biochemistry, Sri Venkateswara University, Andhra Pradesh, India.

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